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目的了解我院神经外科粘质沙雷菌所致下呼吸道感染的现状及耐药性情况,为临床合理用药提供依据。方法收集我院神经外科2008年分离的来自呼吸道标本的72株粘质沙雷菌的药物敏感性试验结果,进行细菌的耐药性分析。结果粘质沙雷菌对青霉素类、一、二、三代头孢菌素类的抗生素的耐药率均较高(>70%),对氨基糖苷的耐药率均较高(>90%),表现为多重耐药,对β内酰胺类复合制剂、喹诺酮类的耐药率较低,对头孢吡肟、亚胺培南均敏感。结论粘质沙雷菌耐药机制复杂,而且对抗生素具有多重耐药性,根据药敏试验合理应用抗菌素十分重要,同时切实加强病区的医院感染管理,防止爆发性流行。
Objective To understand the status and drug resistance of lower respiratory tract infection caused by Serratia marcescens in neurosurgery in our hospital and provide the basis for clinical rational drug use. Methods The drug susceptibility test results of 72 strains of Serratia marcescens isolated from respiratory specimens collected in Department of Neurosurgery of our hospital in 2008 were collected for bacterial resistance analysis. Results Serratia marcescens had a high resistance rate (> 70%) to penicillins, first, second and third generation cephalosporins and a high resistance (> 90%) to aminoglycosides. Showed multi-drug resistance, low resistance to β-lactam compounds, quinolones, and were sensitive to cefepime and imipenem. Conclusion The drug resistance mechanism of Serratia marcescens is complex, and it has multiple drug resistance to antibiotics. It is very important to use antibiotics reasonably according to drug susceptibility test. At the same time, it is necessary to strengthen the management of hospital infection and prevent the outbreak of epidemic.