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目的通过分析我院抗高血压药物的使用情况、为我院今后降压药物药品采购和科学管理提供参考。方法采用DDDs(用药频度)分析方法和处方调阅方法,运用Microsoft execl软件和SPSS10.0版软件,对我院2004年6月-2008年5月抗高血压药物应用情况进行统计分析。结果我院2004年6月-2006年5月与2006年6月-2008年5月两年分组进行对比,钙离子拮抗剂(CCB)应用均为第一名,2004年6月-2006年5月占据DDDs排名第二名的复方制剂在2006年6月-2008年5月降至第6名,2006年6月-2008年5月两年间ACEI类用量明显增多,DDDs排名跃为第二名。联合用药方面,2004年6月-2006年5月单药应用明显多于2006年6月-2008年5月,呈显著差异,P<0.01。两种药物合用,2006年6月-2008年5月多于2004年6月-2006年5月,呈显著差异P<0.05;亚组分析显示,2004年6月-2006年5月以CCB+β-B联合出现频率最高,2006年6月-2008年5月以CCB+ACEI合用出现频率最高。结论钙离子拮抗剂是我院降压药物应用最多的药物,ACEI类药物应用得到了大幅度提高,我院抗高血压药物使用基本合理。
Objective To analyze the use of antihypertensive drugs in our hospital and provide references for the future procurement of antihypertensive drugs and scientific management in our hospital. Methods DDDs (medication frequency) analysis method and prescription retrieval method were used to analyze the application of antihypertensive drugs in our hospital from June 2004 to May 2008 by using Microsoft execl software and SPSS10.0 software. Results In our hospital from June 2004 to May 2006 and June 2006 -2008 in May two-year group comparison, the application of calcium ion antagonist (CCB) are the first, June 2004 -2006 5 DDDs occupy the second place on the list of compound preparations in June 2006 -2008 in May dropped to 6, June 2006 -2008 in May ACEI consumption increased significantly between the two categories, DDDs ranked second in the rankings . In combination therapy, the application of monotherapy was significantly more from June 2004 to May 2006 than that from June 2006 to May 2008, P <0.01. The combination of two drugs, June 2006 -2008 in May than in June 2004 -2006 in May, was significantly different P <0.05; subgroup analysis showed that from June 2004 to May 2006 CCB + β-B joint appeared the highest frequency, June 2006 -2008 in May with CCB + ACEI joint use of the highest frequency. Conclusion Calcium antagonists are the most widely used antihypertensive drugs in our hospital. The application of ACEI drugs has been greatly improved. The antihypertensive drugs used in our hospital are basically rational.