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应用单克隆抗体和ＡＰＡＡＰ法对３５例慢性丙型肝炎患者的外周血Ｔ淋巴细胞亚群的分布进行了检测。结果表明慢性丙肝患者ＯＫＴ＿３￣＋细胞与正常对照无显著差异，而ＯＫＴ＿４￣＋、ＯＫＴ＿８￣＋细胞及ＯＫＴ＿４／ＯＫＴ＿８比值均低于正常对照。结果还表明ＨＢｓＡｇ阴性的丙肝患者细胞和ＯＫＴ＿４／ＯＫＴ＿８比值明显低于正常对照，而ＯＫＴ＿８￣＋细胞差别不显著。合并ＨＢｓＡｇ阳性的丙肝患者ＯＫＴ＿４￣＋、ＯＫＴ＿８￣＋细胞均显著低于正常对照和慢性活动性乙型肝炎患者，而ＯＫＴ＿４／ＯＫＴ＿８比值的差异则不显著，ＯＫＴ＿８￣＋细胞还显著低于ＨＢｓＡｇ阴性的丙肝患者。提示慢性丙型肝炎患者外周血Ｔ淋巴细胞亚群分布存在明显的失衡现象；合并ＨＢｓＡｇ阳性对ＯＫＴ＿８￣＋细胞有明显影响。
The distribution of T lymphocyte subsets in peripheral blood of 35 patients with chronic hepatitis C was detected by monoclonal antibody and APAAP method. The results showed that there was no significant difference between OKT 3+ cells and normal controls in patients with chronic hepatitis C, while the ratios of OKT 4 +, OKT 8 + cells and OKT 4 / OKT 8 were lower than the normal controls. The results also showed that HBsAg-negative hepatitis C cells and OKT_4 / OKT_8 ratio was significantly lower than the normal control, and OKT_8 ~ + cells were not significantly different. OKT_4 ~ + and OKT_8 ~ + cells in HBsAg-positive hepatitis C patients were significantly lower than those in normal control and chronic active hepatitis B patients, while OKT_4 / OKT_8 ratio was not significantly different, OKT_8 ~ + cells were also significantly lower than HBsAg negative Of hepatitis C patients. It is suggested that there is a clear imbalance in the distribution of T lymphocyte subsets in peripheral blood of patients with chronic hepatitis C. The combination of HBsAg positivity has obvious effect on OKT cells.