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慢性胃病伴HP感染的35例患者经丽珠得乐6周加灭滴灵4周治疗.治疗前、治疗后2个月及6个月分别作胃镜检查及钳取胃粘膜组织进行组织学和细菌学检查,同时分别于治疗前、治疗后1个月、2个月、4个月及6个月抽血用酶免疫吸附测定(ELISA)法检测血清抗HP尿素酶抗体IgG.结果:治疗后随着HP的根除和胃炎组织学的好转,抗HP尿素酶抗体IgG在治疗后2个月开始有意义地下降.其中14例观察至治疗后6个月时有11例HP仍保持阴性,其IgG抗体水平继续下降,比治疗前下降35.9 %.3例HP再出现者,其IgG抗体水平下降后又再升高并胃炎组织学加重.结果表明:用ELISA法检测血清抗HP尿素酶抗体IgG对观察抗HP治疗疗效和是否HP再出现是一种有价值的手段.
35 patients with chronic gastropathy and HP infection were treated with Rituximab for 6 weeks and metronidazole for 4 weeks before treatment, 2 months and 6 months after treatment, respectively. Gastroscopy and forceps extraction of gastric mucosa were performed for histology and Bacteriological examination was performed at the same time, and the levels of serum anti-HP urease IgG were detected by enzyme-linked immunosorbent assay (ELISA) before treatment, 1 month, 2 months, 4 months and 6 months after treatment.Results: With the eradication of HP and the improvement of histology of gastritis, anti-HP urease antibody IgG began to decrease meaningfully 2 months after treatment, of which 14 cases observed until 6 months after treatment, 11 cases of HP remained negative, The level of IgG antibody continued to decrease, which was 35.9% lower than that before treatment.The level of IgG antibody in three HP reappeared and then increased again and the histology of gastritis increased.The results showed that serum anti-HP urease antibody IgG on the observation of anti-HP treatment efficacy and whether HP reappearance is a valuable tool.