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40～70％坏死性胰腺炎((NP)患者的坏死胰腺组织沾染有细菌,主要是栖生于肠道的革兰阴性菌。应用杀菌力强、胰腺组织穿透性高的抗生素有助于改善NP的预后。本文研究了不同胰腺疾病状态下胰组织中10种杀菌性抗生素的浓度,并分析胰腺感染时各种抗生素的效能因素(efficacy factor,EF)。材料与方法:病人:89例行胰腺手术患者中包括慢性胰腺炎61例,胰腺或壶腹部周围癌20例,急性NP8例。抗生素选择及用法:硫苯眯唑青霉素4g,氧哌嗪
40 to 70% of necrotic pancreatitis (NP) patients with pancreatic necrosis pancreatic tissue contaminated with bacteria, mainly in the intestinal Gram-negative bacteria. Application of strong bactericidal, pancreatic tissue penetration of antibiotics contribute to Improve the prognosis of NP.This study studied the concentration of 10 kinds of bactericidal antibiotics in pancreatic tissue under different pancreatic disease conditions, and analyzed the efficacy factor (EF) of various antibiotics in pancreatic infection.Materials and Methods: Patient: 89 cases Pancreatic surgery in patients with chronic pancreatitis in 61 cases, 20 cases of pancreatic or ampulla around the cancer, acute NP8 cases antibiotic selection and usage: penicillin 4g, piperazine