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一般说来,用药部位封包增加经皮吸收。但一些作者揭示,亲水性和少数亲脂性化合物如甲醇、乙醇和氢化可的松的通透很少受水合作用或封包的影响。本研究用体外法比较了亲脂性物质5,7-二甲基香豆素(cit-ropten,Ci)和亲脂亲水性物质1,3,7-三甲基黄嘌呤(caffeine,Ca)在封包和不封包条件下的经皮通透情况。实验用皮肤取自一54岁妇女腹部手术后的标本。—18℃保存,用前12小时,在4℃下将皮肤放在铝箔上,仔细去除脂肪,制成16cm~2的皮片。分别将皮肤安装于供样池封顶和不封顶的扩散室装置以代表封包和不封包情况。取160μg/ml 的 Ca、Ci丙酮液一定量于皮肤表面(2.55μg/cm~2),真皮浸在14g/L 的人白蛋白水溶液中,搅拌,实验温度保持37℃。分别于2、4、6、8、12和24小时取接收液用 HPLC 定量,结果以每小
In general, the drug site package increases transdermal absorption. However, some authors have revealed that the permeation of hydrophilic and a few lipophilic compounds such as methanol, ethanol and hydrocortisone is less affected by hydration or encapsulation. This study compared the lipophilic substances 5,7-dimethylcoumarin (cit-ropten, Ci) and lipophilic hydrophilic substances 1,3,7-trimethylxanthine (caffeine, Ca) in vitro Percutaneous permeability under and without encapsulation. The experimental skin was taken from a 54-year-old woman after abdominal surgery. -18 ℃ preservation, with the first 12 hours at 4 ℃ under the skin on the aluminum foil, carefully remove the fat, made of 16cm ~ 2 skin. The skin was installed in the sample pool cap and non-capped diffusion chamber device to represent the package and not packet situation. Take 160μg / ml of Ca, Ci acetone solution on the skin surface (2.55μg / cm ~ 2), the dermis immersed in 14g / L of human albumin aqueous solution, stirring, the experimental temperature was maintained at 37 ℃. Receive liquid at 2, 4, 6, 8, 12, and 24 hours, respectively, and quantify by HPLC