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肝外胆管肿瘤病人生存率较低,外科切除,置管引流和内照射等各种治疗效果均不理想。自1982年作者研究了用血卟啉衍生物或双血卟啉醚(DHE)做为激活剂的光效应疗法(PDT),以及它对各种恶性肿瘤的疗效和副作用。当静脉注射这种光激活剂后,其在体内广泛分布。由于未知的原因,这种激活剂在正常组织迅速清除而存留于肿瘤组织内,二天后癌细胞含有高于邻近正常组织浓度的激活剂并吸收某些可见光。最大吸收是在405 nm(蓝绿),另一吸收峰在630 nm(红色),后者穿透组织能力强更利于该治疗。光被吸收后激活染料产生单氧,引起肿瘤组织死亡。正常组织所含染料浓度低不足以引起这种光效不受损害。
The survival rate of patients with extrahepatic bile duct tumors is low, surgical resection, catheter drainage and internal irradiation and other treatment effects are not ideal. Since 1982, the authors studied light-effect therapy (PDT) using hematoporphyrin derivatives or dihematoporphyrin ether (DHE) as activators, as well as its efficacy and side effects on various malignancies. When intravenously injected with this photoactivator, it is widely distributed in the body. For unknown reasons, this activator rapidly clears in normal tissues and remains in the tumor tissue. Two days later, the cancer cells contain an activator at a higher concentration than the adjacent normal tissue and absorb some visible light. The maximum absorption is at 405 nm (blue-green), and the other absorption peak is at 630 nm (red). The latter’s ability to penetrate the tissue is more conducive to this treatment. After the light is absorbed, the dye is activated to produce monooxygen, causing tumor tissue death. The low concentration of dye contained in normal tissue is not sufficient to cause this light effect to be impaired.