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目的 :探讨高血压病患者血清肝细胞生长因子 (HGF)水平与低密度脂蛋白 (LDL)及左室重塑的关系。方法 :将 6 5例 2级原发性高血压 (EH)患者分成单纯高血压组、高低密度脂蛋白 (LDL)组和左室重塑组。用酶联免疫吸附法 (ELISA)测定血清HGF水平。结果 :血清HGF浓度与舒张压无显著相关 (r =0 .0 39,P >0 .0 5 ) ;而与收缩压及LDL浓度呈正相关 (分别r=0 .4 6 ,r =0 .6 7,均P <0 .0 5 ) ,且高LDL组和左室重塑组血清HGF均较单纯高血压组显著升高 (均P <0 .0 1) ,单纯高血压组较正常对照组明显升高 (P <0 .0 1)。结论 :血清HGF水平与左室重塑、LDL及高血压本身有关 ,HGF可作为判断高血压病严重程度的指标之一。
Objective: To investigate the relationship between serum hepatocyte growth factor (HGF) and low density lipoprotein (LDL) and left ventricular remodeling in patients with essential hypertension. Methods: Sixty-five patients with grade 2 essential hypertension (EH) were divided into simple hypertension group, high-density low density lipoprotein (LDL) group and left ventricular remodeling group. Serum HGF levels were measured by enzyme-linked immunosorbent assay (ELISA). Results: Serum HGF concentration had no significant correlation with diastolic pressure (r = 0.39, P> 0.05), but was positively correlated with systolic blood pressure and LDL concentration (r = 0.46, r = 0.6 7, all P <0.05), and the levels of serum HGF in high LDL group and left ventricular remodeling group were significantly higher than those in simple hypertension group (all P <0.01). Compared with normal control group Was significantly higher (P <0.01). Conclusion: The level of serum HGF is related to left ventricular remodeling, LDL and hypertension itself. HGF can be used as one of the indicators to judge the severity of hypertension.