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在非胰岛素依赖型糖尿病(NIDDM)病人中。冠心病和脑血管意外的患病率较非糖尿病病人高2～3倍,是近代糖尿病人的主要死亡原因。虽然促成糖尿病人动脉粥样化的因素很多,但脂代谢紊乱作为主要原因是无可质疑的。NIDDM脂代谢紊乱常为混合型,尤以女性更为常见。因此,在对NIDDM病人控制中,纠正脂代谢异常有重要意义。本文拟就HMG-CoA还原酶抑制剂的药理作用及其在NIDDM脂代谢异常中的应用作扼要介绍。
In non-insulin dependent diabetes mellitus (NIDDM) patients. Coronary heart disease and cerebrovascular accident prevalence than non-diabetic patients 2 to 3 times higher, is the main cause of death in modern diabetes. Although there are many factors contributing to atherosclerosis in diabetic patients, the main cause of dyslipidemia is beyond doubt. NIDDM lipid metabolism often mixed, especially in women is more common. Therefore, in the control of NIDDM patients, to correct lipid metabolism abnormalities of great significance. This article is intended to summarize the pharmacological effects of HMG-CoA reductase inhibitors and their application in the abnormal lipid metabolism of NIDDM.