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以芝麻酚和芳香醛为主要原料,经傅-克酰基化、关环和羟醛缩合反应,设计合成了14个未见文献报道的橙酮类似物,其结构均经1H NMR、MS和IR确证。初步抑菌活性测定结果表明:在100 mg/L下,所有目标化合物对7种供试病原菌均有不同程度的抑制作用,其中化合物3a、3b、3c和3d对番茄灰霉病菌Botrytis cirerea的抑制率达到100%,3g对小麦赤霉病菌Fusarium graminearum、玉米弯孢叶斑病菌Curvulavia lunata、棉花枯萎病菌Fusarium oxysporum vasinfectum、水稻稻瘟病菌Magnaporthe grisea的抑制率均大于80%,3m对马铃薯干腐病菌Fusarium solani和玉米弯孢叶斑病菌的抑制率分别为100%和83.8%。
Fourteen new compounds were synthesized and synthesized by the method of Friedel-Crafts acylation, ring closure and aldol condensation. The structures of the compounds were characterized by 1H NMR, MS and IR Confirmed. The results of the preliminary antibacterial activity test showed that all the target compounds inhibited the seven tested pathogens to a certain extent at 100 mg / L, and the inhibitory effects of the compounds 3a, 3b, 3c and 3d on the Botrytis cirerea The inhibition rates of 3g to Fusarium graminearum, Curvulavia lunata, Fusarium oxysporum vasinfectum and Magnaporthe grisea were all higher than 3% The inhibitory rates of Fusarium solani and Curvularia lunata were 100% and 83.8%, respectively.