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目的溴隐亭及多巴胺受体D2激动剂会影响除人以外其它灵长类动物的一系列行为,特别是与运动和心理活动相关的行为,比如动物会表现出抑制性行为及幻觉样行为。除药物外,快速眼动睡眠(REM)机制的紊乱也可导致幻觉。打乱清醒、REM及非快速眼动睡眠(NREM)的规律可引起一系列精神病症状。方法当动物处于清醒,NREM和REM及药物导致的类精神病状态时,同时记录五个皮层脑区的听觉诱发电位,从而研究对比不同状态下听觉诱发电位的变化。结果在幻觉状态及REM期,前额叶背外侧皮层记录到的潜伏期为250ms的诱发电位成分出现波峰到基线的相位翻转(PBA250),说明幻觉状态及REM在前额叶背外侧皮层有类似的调节机制。结论在前额叶背外侧皮层记录到的N250可以用来判断幻觉样行为是否出现,这表明前额叶背外侧皮层可能同幻觉样行为最相关。
Purpose Bromocriptine and dopamine D2 agonists affect a range of behaviors of other primates other than humans, particularly those related to physical and mental activity, such as animals that exhibit inhibitory behavior and hallucination-like behaviors. In addition to the medication, disorders of the REM sleep mechanism can also lead to hallucinations. Disturbing soberness, REM and non-REM sleep patterns can cause a number of psychotic symptoms. Methods The auditory evoked potentials of five cortical brain regions were recorded at the same time when the animals were awake, NREM, REM and drug-induced psychosis. The auditory evoked potentials were compared under different conditions. Results In the hallucinated state and the REM phase, the peak-to-baseline phase inversion (PBA250) of the evoked potential component recorded in the dorsolateral prefrontal cortex with a latency of 250 ms demonstrated a similar regulatory mechanism of hallucination and REM in the dorsolateral prefrontal cortex . Conclusion N250 recorded in the dorsolateral prefrontal cortex can be used to determine whether illusion-like behavior is present, suggesting that the dorsolateral prefrontal cortex may correlate most with hallucinations.