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目的 :探讨慢性阻塞性肺疾病(COPD)患者血D-二聚体(D-D)及胆红素检测的临床意义。方法 :选取COPD急性加重期患者79例、缓解期患者88例及76例健康体检者为对照组,检测血D-D及胆红素水平,分析D-D水平与胆红素的相关性。结果:COPD缓解期及急性加重期患者D-D水平均高于正常对照组,总胆红素(TBIL)、直接胆红素(DBIL)及间接胆红素(IBIL)水平均低于正常对照组(P<0.05或P<0.01);COPD急性加重期患者D-D水平高于缓解期患者,TBIL、DBIL及IBIL水平则低于缓解期患者(P<0.05或P<0.01)。COPD患者D-D水平与TBIL(r=-0.474,P<0.01)及IBIL(r=-0.365,P<0.05)呈负相关。结论:血D-D水平增高及胆红素水平降低与COPD的急性加重有关,动态监测D-D及胆红素水平变化对判断COPD病情发展有一定指导意义。
Objective: To investigate the clinical significance of detecting D-D and bilirubin in patients with chronic obstructive pulmonary disease (COPD). Methods: A total of 79 patients with acute exacerbation of COPD, 88 patients with remission and 76 healthy controls were selected as control group. The levels of D-D and bilirubin were measured and the correlation between D-D and bilirubin was analyzed. Results: The levels of DD in patients with COPD in remission and acute exacerbation were higher than those in control group. The levels of total bilirubin (TBIL), direct bilirubin (DBIL) and indirect bilirubin (IBIL) were lower than those in control group (P <0.05 or P <0.01). The level of DD in patients with acute exacerbation of COPD was higher than those in patients in remission, while the levels of TBIL, DBIL and IBIL were lower in patients with remission (P <0.05 or P <0.01). D-D levels in COPD patients were negatively correlated with TBIL (r = -0.474, P <0.01) and IBIL (r = -0.365, P <0.05). CONCLUSION: Increased blood D-D level and decreased bilirubin levels are associated with acute exacerbations of COPD. Dynamic monitoring of D-D and bilirubin levels may be of guiding significance in judging the progression of COPD.