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目的 观察紫外线照射充氧自血回输（ＵＢＩＯ）治疗老年消化性溃疡的疗效和机制。方法 将６０ 例老年消化性溃疡患者随机分成二组，３０ 例采用ＵＢＩＯ 疗法并用雷尼替丁，另３０ 例作为对照组仅服雷尼替丁。ＵＢＩＯ每周３ 次，４ 周１ 疗程。结果 ＵＢＩＯ组和对照组溃疡愈合率分别为９０ ％（２７／３０）和６７％ （２０／３０），χ２ ＝ ４ ．８１ ，Ｐ＜ ０．０５，差异有显著性；幽门螺杆菌（ＨＰ） 阴转率分别为５８ ％（１４／２４）和９ ％ （２／２３），χ２ ＝ １２．８９ ，Ｐ＜ ０ ．０１，差异有非常显著性；ＵＢＩＯ 组疗程前后纤维蛋白原、全血粘度、红细胞聚集指数等方面改善非常显著（ Ｐ＜ ０ ．０５ ～０ ．０１） ，血浆铜锌超氧化物歧化酶（ＳＯＤ－ １）明显升高。溃疡愈合患者随访１ 年，溃疡复发率ＵＢＩＯ 组为２１％ （５／２４） ，对照组为５６％ （１０／１８） ，χ２＝５ ．４０ ，Ｐ＜ ０ ．０５ ，差异有显著性。结论 ＵＢＩＯ 能明显降低血液粘稠度，杀灭ＨＰ，提高ＳＯＤ－ １ 含量，它既能清除攻击因子又能增强防御因子，明显地提高老年消化性溃疡的愈合率，降低复发率。
Objective To observe the curative effect and mechanism of ultraviolet ray irradiation (UBIO) on senile peptic ulcer. Methods Sixty elderly patients with peptic ulcer were randomly divided into two groups: 30 patients received ranitidine by UBIO and the other 30 patients served as the control group only ranitidine. UBIO 3 times a week, 4 weeks 1 course of treatment. Results The rates of ulcer healing in UBIO group and control group were 90% (27/30) and 67% (20/30), respectively. Χ2 = 4. 81, P <0.05, the difference was significant. The negative conversion rates of Helicobacter pylori (HP) were 58% (14/24) and 9% (2/23) respectively, and χ2 = 12.89, P < 01, the difference was very significant; UBIO group before and after treatment fibrinogen, whole blood viscosity, erythrocyte aggregation index and other aspects of the improvement is very significant (P0.05 ~ 0.01), plasma copper and zinc superoxide dismutase (SOD - 1) Significantly increased. The ulcer healing patients were followed up for 1 year, the ulcer recurrence rate was 21% (5/24) in UBIO group and 56% (10/18) in control group, χ2 = 5. 40, P <0. 05, the difference was significant. Conclusion UBIO can significantly reduce blood viscosity, kill HP and increase the content of SOD-1. It can not only remove the attack factor but also enhance the defense factor, obviously improve the healing rate of peptic ulcer and reduce the recurrence rate.