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癫痫病人比一般人群更常见抑郁,抗抑郁剂一般都有潜在的致痫作用,因而对癫痫病人抗抑郁治疗甚感困难。实验和临床都显示乙氧苯氧甲吗啉(Viloxazine,VLX)无或至少比其它抗抑郁剂较少具有致痫作用,表明VLX 可能是治疗这种病人的一种可供选择的药物。既往试验中,作者曾发现VLX 能抑制卡马西平代谢,引起卡马西平中毒的临床征象。为了解VLX 是否对苯妥因(PHT)也有类似作用,作者研究了10例癫痫病人(7男、3女),年龄在42～72岁间,至少用PHT 标准剂量3月,并无不
Epilepsy patients are more common depression than the general population, antidepressants generally have potential epileptic effects, and thus anti-depression treatment of epilepsy patients is very difficult. Both experimental and clinical evidences show that Viloxazine (VLX) has no or at least epileptogenic effects compared to other antidepressants, suggesting that VLX may be an alternative drug for this type of patient. Previous experiments, the authors have found that VLX can inhibit carbamazepine metabolism, causing clinical signs of carbamazepine poisoning. To understand whether VLX has a similar effect on PHT, the authors studied 10 patients with epilepsy (7 males and 3 females) aged 42-72 years with at least the standard PHT dose of March