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1948年Benson等将己内酰胺(1)和硫酸二甲酯在不同条件下反应,得到两个异构的甲基化产物.他们根据产物的反应性能指定一个产物为O-甲基己内酰亚胺(2),另一个产物为N-甲基已内酰胺(3).作者应用~1H NMR进一步证实了Benson等所推断的这两个化合物的结构.2和3的波谱数据只见过零星报道,且未作对比解析.本文除了探讨1和硫酸二甲酯的摩尔配比是否是反应生成2或3的主要因素外,还测定了2和3的紫外光谱、红外光谱、核磁共振谱及质谱.
In 1948, Benson et al. Reacted caprolactam (1) with dimethyl sulfate under different conditions to obtain two isomeric methylated products. They designated one product as O-methylcaprolactam according to the reaction performance of the product (2), and the other product is N-methyl caprolactam (3). The application of ~ 1H NMR further confirmed the structures of these two compounds deduced by Benson et al. The spectral data of 2 and 3 were only seen in sporadic reports , And no comparative analysis.In addition to discussing whether the molar ratio of 1 and dimethyl sulfate is the main factor for the reaction to produce 2 or 3, the UV spectra, IR spectra, NMR spectra and mass spectra .