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强力霉素(简称α-体)生产中氢化产物是较为复杂的.其中不仅有未反应的原料甲烯土霉素,而且还有副产物如强力霉素的差相异构体——β-强力霉素(简称β-体)和结构未知的氢化产物(生产上习称“前沿”).因此,氢化工艺中的耗氢量并不能反映α-体的产量.若采用强力霉素的成品分析法——生物效价法则因这些杂质不仅含量高,而且又有一定的生物活性,故使该法也不能应用.若采用薄层层折法检查,虽能查出这些杂质是否存在,但难于对α-体含量直接进行测定.为了掌握氢化进程,判断催
The production of hydrogenated products in the production of doxycycline (a-body) is more complicated, in which not only the unreacted raw material meta-oxytetracycline, but also the by-products such as the differential isomer of doxycycline- Therefore, the hydrogen consumption in the hydrogenation process does not reflect the production of a-body.If the product with doxycycline (referred to as β-body) and unknown structure of the hydrogenated product Analytical method - the biological potency law because of these impurities not only high content, but also a certain degree of biological activity, so the law can not be applied.If the thin layer test, although these impurities can be detected, but It is difficult to determine the content of a-body directly. In order to master the hydrogenation process, determine the reminder