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36例胰腺癌患者,按肿瘤切除与否分为手术切除组和未切除组,每组均为18例。应用全自动图像分析仪测定癌细胞核形态学参数及DNA含量。结果表明两组核形态学参数无差异(P>0.05);未切除组癌细胞光密度,u值和异倍体率较手术切除组高(P<0.01)。进一步回归分析表明:在15项指标中,影响胰腺癌手术切除性的有4个因素,依次为癌细胞光密度、u值、DNA倍型和临床分期。
Thirty-six patients with pancreatic cancer were divided into surgical resection group and unresectable group according to the resection of the tumor. There were 18 cases in each group. The nuclear morphological parameters and DNA content of cancer cells were determined using a fully automatic image analyzer. The results showed that there was no difference in the nuclear morphological parameters between the two groups (P>0.05); the optical density, u value and aneuploidy of the unremoved group were higher than those in the surgical resection group (P<0.01). Further regression analysis showed that among the 15 indicators, there were 4 factors that affected surgical resection of pancreatic cancer, which were cancer cell optical density, u value, DNA ploidy, and clinical stage.