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探讨ｎｍ２３基因产物／ＮＤＰＫ表达与胃癌、大肠癌细胞核ＤＮＡ含量的关系。方法：ｎｍ２３基因产物／ＮＤＰＫ表达阴性、弱阳性及强阳性的胃癌、大肠癌共５７例（胃癌各１１例、大肠癌各８例），使用ＤＮＡ图像分析技术检测癌细胞核ＤＮＡ含量。结果：ｎｍ２３／ＮＤＰＫ表达阴性的胃癌或大肠癌细胞核ＤＮＡ含量显著高于ｎｍ２３／ＮＤＰＫ阳性表达者（分别为Ｐ＜００５，Ｐ＜０００１）；在ＤＮＡ倍体分布形式上，ｎｍ２３／ＮＤＰＫ阴性的胃癌和大肠癌中二倍体细胞的检出率较低（分别为Ｐ＜００５、Ｐ＜０００１）；而非整倍体细胞检出率则显著高于ｎｍ２３／ＮＤＰＫ阳性表达者（分别为Ｐ＜００５、Ｐ＜０００１）；结论：ｎｍ２３基因产物／ＮＤＰＫ失表达与胃癌、大肠癌非整倍体细胞形成有关。
To explore the relationship between nm23 gene product/NDPK expression and nuclear DNA content in gastric cancer and colorectal cancer. METHODS: A total of 57 cases of gastric cancer and colorectal cancer with negative expression of nm23 gene product/NDPK expression, weak positive, and strong positive were included (11 cases of gastric cancer and 8 cases of colorectal cancer). The DNA content was detected by DNA image analysis. RESULTS: The nuclear DNA content of gastric cancer or colorectal cancer with negative expression of nm23/NDPK was significantly higher than that of nm23/NDPK positive expression (P<005, P<0001, respectively); in the form of DNA ploidy distribution, nm23/ The detection rate of diploid cells in NDPK-negative gastric cancer and colorectal cancer was low (P<005, P<0001, respectively); the detection rate of non-euploid cells was significantly higher than that of nm23/NDPK. Positive expression (P<005, P<0001, respectively); Conclusion: The loss of expression of the nm23 gene product/NDPK is associated with the formation of aneuploid cells in gastric cancer and colorectal cancer.