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目的研究Maspin mRNA在肺鳞状细胞癌组织中的表达及其与临床病理因素之间的关系,并分析其对预后生存的影响。方法采用免疫原位杂交法检测Maspin mRNA在肺鳞状细胞癌组织及癌旁组织中的表达。结果Maspin mRNA在癌旁组织、肺鳞状细胞癌组织中的阳性表达率分别为80.00%、41.43%,差异有统计学意义(χ2=12.54,P<0.01)。Maspin mRNA的阳性表达与患者年龄、性别、淋巴结转移无关,差异无统计学意义(P>0.05),但与肿瘤直径、组织学分级、TNM分期及增殖活性Ki-67有关,差异有统计学意义(P<0.05)。Maspin mRNA阴性表达患者生存率与阳性表达患者生存率比较,差异均无统计学意义(χ2=0.03,P=0.87)。结论 Maspin mRNA表达可反映肺鳞状细胞癌的恶性程度,但不能反映患者的预后生存。
Objective To investigate the expression of Maspin mRNA in lung squamous cell carcinoma (SCC) and its relationship with clinicopathologic factors and to analyze its effect on prognosis. Methods Maspin mRNA was detected by immunohistochemistry in lung squamous cell carcinoma and adjacent normal tissues. Results The positive expression rates of Maspin mRNA in paracancer tissues and lung squamous cell carcinoma tissues were 80.00% and 41.43%, respectively, with significant difference (χ2 = 12.54, P <0.01). The positive expression of Maspin mRNA was not related to the age, sex and lymph node metastasis of patients (P> 0.05), but was related to tumor diameter, histological grade, TNM staging and proliferative activity Ki-67, the difference was statistically significant (P <0.05). There was no significant difference in the survival rates of patients with maspin mRNA negative expression and those with positive expression (χ2 = 0.03, P = 0.87). Conclusion Maspin mRNA expression can reflect the degree of malignancy of squamous cell lung cancer, but can not reflect the prognosis of patients with survival.