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1962年 Mokler 和 Van Araman 报导过双异丙吡胺(以下简称 DPM)的抗心律失常作用,发现它对电或鸟头碱诱发的实验性房性心律失常以及由毒毛旋花子素或 Harris氏二期冠脉结扎所诱发的室性心律失常治疗有效。该药抗心律失常的浓度对血液动力学很少有或者没有有害的作用,而有轻微的付交感神经作用,对心脏的交感神经功能无作用。在最初研究时,该药抗心律失常有效浓度相当于奎尼丁的1/2或1/3。临床应用和临床毒性DPM 治疗心律失常已众所周知,在欧洲首先应用,成功地用于治疗阵发性室上性心
Mokler and Van Araman (1962) reported the anti-arrhythmic effect of disopyramide (hereinafter DPM) and found that it exerts anti-arrhythmic effects on either electrical or head-induced experimental atrial arrhythmias, Secondary coronary artery ligation induced ventricular arrhythmia treatment effective. The anti-arrhythmic concentration of this drug has little or no adverse effect on hemodynamics and a slight sympathetic effect on the sympathetic function of the heart. In the initial study, the drug anti-arrhythmic effective concentration equivalent to quinidine 1/2 or 1 / Clinical and Clinical Toxicity DPM for the treatment of arrhythmias is well known and first applied in Europe and has been successfully used in the treatment of paroxysmal supraventricular