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目的探讨在慢性阻塞性肺疾病(COPD)急性发作期患者中,布地奈德氧气雾化吸入对患者呼吸应答中的影响。方法以上蔡县人民医院在2012年3月至2014年6月收治的84例COPD急性发作期患者作为研究对象,按照随机分布的方式将其分为试验组与对照组,每组42例。给予对照组常规治疗,试验组在常规治疗的基础上,给予布地奈德氧气雾化吸入治疗,观察两组患者的临床效果,比较两组患者治疗前后的胸肺顺应性、气体交换情况。结果在患者的胸肺顺应性改善状况方面,两组患者治疗前肺顺应性(CL)、总顺应性(CT)及胸廓顺应性(CTh)水平比较差异均未见统计学意义(P>0.05)。治疗后,两组患者的CL、CT、CTh水平均得到明显提高,且治疗后,试验组患者的CL、CT、CTh水平均明显高于对照组,差异有统计学意义(P<0.05)。同时,在两组患者气体交换情况方面,两组患者治疗前,两组患者的FEV1.0(1 s用力呼气量)、PEF(峰值呼气流速)、最大吸气压(MIP)、最大呼气压(MEP)指标差异均未见统计学意义(P>0.05),经过连续1周的治疗后,两组患者的FEV1.0、MIP、PEF、MEP指标均得到提升,且治疗后,试验组患者的FEV1.0、MIP、PEF、MEP的改善水平明显优于对照组,差异有统计学意义(P<0.05)。结论利用布地奈德氧气雾化吸入治疗COPD急性发作期患者,可有效改善患者的呼吸应答,提高治疗效果,具有较高的临床推广价值。
Objective To investigate the effect of inhaled budesonide oxygen inhalation on respiratory responses in patients with acute exacerbation of chronic obstructive pulmonary disease (COPD). Methods Eighty-four patients with acute exacerbation of COPD were enrolled in this study from March 2012 to June 2014 in Caixian People’s Hospital. Patients were randomly divided into trial group and control group, with 42 cases in each group. The control group was given routine treatment. The experimental group was given budesonide oxygen inhalation therapy on the basis of routine treatment. The clinical effects of the two groups were observed. The compliance and gas exchange between the two groups before and after treatment were compared. Results There was no significant difference in lung compliance (CL), total compliance (CT) and thoracic compliance (CTh) between the two groups before treatment in terms of patients’ improvement of chest and lung compliance (P> 0.05 ). After treatment, the levels of CL, CT and CTh in both groups were significantly increased. After treatment, the levels of CL, CT and CTh in the experimental group were significantly higher than those in the control group (P <0.05). At the same time, the two groups of patients before treatment, the two groups of patients FEV1.0 (1s forced expiratory volume), PEF (peak expiratory flow), the maximum inspiratory pressure (MIP), the largest There was no significant difference in MEP index between the two groups (P> 0.05). After 1 week of continuous treatment, the FEV1.0, MIP, PEF and MEP indices of both groups were improved. After treatment, The improvement of FEV1.0, MIP, PEF and MEP in the experimental group was significantly better than that in the control group, with significant difference (P <0.05). Conclusion The use of budesonide aerosol inhalation in patients with acute exacerbation of COPD can effectively improve the patient’s respiratory response and improve the treatment effect, with a high clinical value.