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目的观察南阳市第三人民医院接诊的镇静药物急性中毒病例的临床症状,研究治疗措施,完善抢救方案。方法随机选取40例超大剂量氯氮平和舒必利急性患者,采用回顾性研究的方法,根据患者临床病症表现,通过对诊断和预后等项目进行分析。结果冬季患者占全年病例的62.5%;自杀人数占治疗总数的80%;中学文化水平者和普通打工者人员占患者各占总数的42%、50%;药物多通过消化道系统破坏体内器官,重度中毒19例,占47.5%,中度中毒12例,占30.0%,轻度中毒9例,占22.5%;治疗费用少于2500元者30例,占75.0%,2500~5000元者10例,占25%;接受洗胃治疗40例(100%),药物检测15例(37.5%);使用利尿剂22例,抗感染药物40例,解毒剂35例;经抢救治疗,治完全治愈35例,治疗无效5例。治愈成功病例率与失败病例率相比差异有统计学意义(P<0.05)。结论从病症高发时间方面看,患者多集中于冬季;从发病原因进行分析,自杀人数较多;从患者的文化程度和职业等方面分析,文化素质较低,职业不理想;从中毒程度剖析,患者的中毒情况均比较严重;从患者的治疗花费情况分析,平均花费较低;从治疗方式分析,患者一般需要经受洗胃治疗;从补液种类分析,需要对患者进行防感染治疗;经过临床抢救后,大多数患者均能够生还,治疗愈率高。
Objective To observe the clinical symptoms of acute sedation poisoning in the Third People’s Hospital of Nanyang City and to study the treatment measures and improve the rescue plan. Methods Forty acute hypercholesterolemic patients who were treated with clozapine and sulpiride at random were selected and retrospectively studied. According to the clinical manifestation of the patients, the items such as diagnosis and prognosis were analyzed. Results The number of sufferers accounted for 80% of the total number of sufferers in winter. The percentage of middle school students and ordinary migrant workers accounted for 42% and 50% respectively of the total number of sufferers. Drugs mostly destroyed the internal organs through the digestive system , Severe poisoning in 19 cases, accounting for 47.5%, moderate poisoning in 12 cases, accounting for 30.0%, mild poisoning in 9 cases, accounting for 22.5%; treatment costs less than 2500 yuan in 30 cases, accounting for 75.0%, 2500-5000 yuan 10 Cases, accounting for 25%; gastric lavage treatment in 40 cases (100%), drug detection in 15 cases (37.5%); the use of diuretics in 22 cases, 40 anti-infective drugs, antidote in 35 cases; 35 cases, 5 cases of ineffective treatment. There was significant difference between the success rate of cure and the failure rate (P <0.05). Conclusions From the point of view of the high incidence of illness, most patients are concentrated in the winter; from the analysis of the cause of the disease, there are more suicides; from the analysis of the patient’s education level and occupation, the education level is low and the career is not ideal; from the analysis of the degree of poisoning, The patient’s poisoning situation is more serious; from the patient’s treatment cost analysis, the average cost is low; from the treatment analysis, patients generally need to undergo gastric lavage treatment; from the fluid type analysis, the need for anti-infection treatment; after clinical rescue After most patients are able to survive, the cure rate is high.