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目的探讨长期家庭无创机械通气对于慢性阻塞性肺疾病(COPD)合并呼吸衰竭患者的血清甲状腺素含量的影响。方法选取2009年7月至2013年7月在孝感市中心医院治疗的慢性阻塞性肺疾病合并慢性呼吸衰竭患者50例,将长期家庭无创机械通气及吸氧的患者作为治疗组,共11例;未使用吸氧及机械通气的患者作为对照组,共39例。两组患者采用的基础治疗无差异,均随访1年,比较两组患者的血清甲状腺素含量。结果慢性呼吸衰竭患者应用家庭无创通气及吸氧后血清T3、T4、TSH含量较对照组明显升高(P<0.05)。结论对COPD合并慢性呼吸衰竭患者实施家庭无创机械通气机吸氧,可以明显升高患者血清甲状腺素含量。
Objective To investigate the effect of long-term home-based non-invasive mechanical ventilation on serum thyroxine levels in patients with chronic obstructive pulmonary disease (COPD) and respiratory failure. Methods 50 patients with chronic obstructive pulmonary disease and chronic respiratory failure who were treated in Xiaogan Central Hospital from July 2009 to July 2013 were selected as the treatment group with long term noninvasive mechanical ventilation and oxygen inhalation as the treatment group. 39 patients who did not use oxygen inhalation and mechanical ventilation as the control group. The two groups of patients with no difference in basic treatment, were followed up for 1 year, comparing the two groups of patients with serum thyroxine levels. Results The levels of serum T3, T4 and TSH in patients with chronic respiratory failure were significantly higher than those in control group after non-invasive ventilation and oxygen inhalation (P <0.05). Conclusion Oxygen inhalation of noninvasive mechanical ventilator in family with COPD and chronic respiratory failure can significantly increase serum thyroxine levels in patients.