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通过复制家兔动脉粥样硬化(AS)模型,测定血浆脂蛋白、前列腺素水平、血小板聚集(PMAR)及主动脉组织 Ch、AppB 含量和粥样病变面积,探讨血浆脂蛋白与血小饭的相关性及与二者与主动脉粥样病变的相关性。结果显示:PMAR 与血浆总胆固醇(TC、r=0.727)、血浆甘油三脂(TG,r=0.502)、血浆低密度脂蛋白胆固醇(LDL-Ch,r=0.705)、血浆载脂蛋白 B(ApoB,r=0.751)均呈直线正相关(P 均<0.01),与 HDL_2-Ch(r=-0.444),HDL-Ch/TC(r=-0.584)均呈直线负相关(P 均<0.01),主动脉组 Ch、ApoB 含量及粥样病变面积各自与血浆 ApoB,PMAR 呈正相关(P 均<0.05～0.0),而与血浆 HDL_2-Ch 里负相关(P 均<0.05～0.01)。结果提示:血浆 TC、TG、LDL-Ch、ApoB 升高具有激活血小板致 AS 作用.而 HDL_2-Ch,HDL-Ch/TC 升高再有抑制血小板抗 AS 作用
The plasma lipoprotein, prostaglandin levels, platelet aggregation (PMAR), Ch, AppB content in aortic tissue, and atherosclerotic lesion area were determined by replicating the rabbit atherosclerosis (AS) model to investigate the relationship between plasma lipoprotein and blood meal. Correlations and their association with aortic atherosclerosis. The results showed: PMAR and plasma total cholesterol (TC, r=0.727), plasma triglyceride (TG, r=0.502), plasma low-density lipoprotein cholesterol (LDL-Ch, r=0.705), plasma apolipoprotein B ( ApoB,r=0.751) all showed a positive linear correlation (P<0.01) and a negative linear correlation with both HDL-Ch (r=-0.444) and HDL-Ch/TC (r=-0.584) (P <0.01 ), Ch, ApoB content and atherosclerotic lesion area in the aortic group were positively correlated with plasma ApoB, PMAR (P <0.05 ~ 0.0), but negatively correlated with plasma HDL 2 - Ch (P <0.05 ~ 0.01). The results suggest that elevated levels of plasma TC, TG, LDL-Ch, and ApoB have the effect of activating platelet-induced AS, while elevated HDL-Ch and HDL-Ch/TC inhibit platelet-resistance to AS.