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目的:通过对去势大鼠骨密度的观察,为超微金刚治疗骨质疏松症的临床应用提供实验依据。方法:将50只10月龄Wistar雌性大鼠随机分为5组:空白对照组、假手术组、模型组、超微金刚组、骨疏康颗粒组;治疗组及模型组采用去除大鼠双侧卵巢,假手术切除相同重量肠系膜。使用X线骨密度仪,测定大鼠右后肢股骨;观察去势大鼠BMD指标的影响。结果:骨密度测定显示,正常组、超微金刚组、骨疏康颗粒组BMD值均高于模型组,差异有统计学意义(P<0.05);正常组与超微金刚组、骨疏康颗粒组之间比较,差异无统计学意义(P>0.05),不具有可比性。实验表明去势大鼠模型造模成功,超微金刚与骨疏康颗粒均有阻止去势大鼠BDM降低的功效。结论:超微金刚能够明显提高去势大鼠的股骨密度的表达水平,表明超微金刚可以有效阻止或减缓骨吸收,达到治疗骨质疏松症的作用。
Objective: To observe the bone mineral density of ovariectomized rats and provide experimental evidence for the clinical application of micro-diamond therapy in osteoporosis. Methods: Fifty Wistar female rats of 10 months old were randomly divided into 5 groups: control group, sham operation group, model group, DHA group and Gushukang Granule group. The treatment group and model group Side of the ovary, sham resection of the same weight mesentery. The X-ray bone densitometer was used to determine the right hind femur in rats. The effects of BMD on ovariectomized rats were observed. Results: The bone mineral density (BMD) showed that the BMD of normal group, PCG and Gushukang granule group were higher than that of model group (P <0.05) There was no significant difference between the granule groups (P> 0.05), which was not comparable. Experiments show that castrated rat model successful model, AMD and Gushukang particles have the effect of preventing BDM in ovariectomized rats. Conclusion: DHA can significantly increase the expression of femur density in ovariectomized rats, indicating that DHA can effectively prevent or slow bone resorption and achieve the effect of treating osteoporosis.