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目的评价血清D-二聚体、细胞角蛋白21-1片段(CYFRA21-1)癌胚抗原(CEA)联合检测在肺癌诊断中的价值。方法将100例肺癌患者按TNM分期法分为四期:Ⅰ～Ⅱ期组(63例),Ⅲ～Ⅳ期组(37例),肺良性疾病组32例,48例正常为对照组,测定以上三项指标。结果肺癌组血清CYFRA21-1、D-二聚体、CEA水明显高于肺良性疾病组(P<0.05)。3项指标联合在肺癌的不同期也存在差别。结论联合检测血清或血浆CYFRA21-1、D-二聚体、CEA可弥补单一指标的不足,提高肺癌的检出率,对肺癌的诊断和预后判断也具有一定的价值。
Objective To evaluate the value of combined detection of serum D-dimer and cytokeratin 21-1 (CYFRA21-1) carcinoembryonic antigen (CEA) in the diagnosis of lung cancer. Methods 100 cases of lung cancer patients were divided into four phases according to the TNM staging method: I-II phase group (63 cases), III-IV phase group (37 cases), benign lung disease group 32 cases, 48 cases were normal control group. The above three indicators. Results The levels of serum CYFRA21-1, D-dimer and CEA in lung cancer group were significantly higher than those in benign lung disease group (P<0.05). The combination of the three indicators also differed in different stages of lung cancer. Conclusion Combined detection of serum or plasma CYFRA21-1, D-dimer and CEA can make up for the deficiency of single index, increase the detection rate of lung cancer, and have certain value in the diagnosis and prognosis of lung cancer.