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目的了解血清CEA阴性结直肠癌的临床和流行病学特征。方法回顾性分析2003年1月～2010年12月术前有血清CEA检测结果的新发结直肠癌住院病例1969例,比较血清CEA阴性和CEA阳性两组结直肠癌资料。结果术前CEA阴性结直肠癌与CEA阳性结直肠癌相比,前者平均发病年龄为(55.89±13.68)岁,较后者年轻2岁多;中位发病年龄为56岁,较后者提前3岁;发病人群以60岁以下的青壮年占多数,其中血型A者所占比例较高,而血型B者所占比例较低;血清CEA表达状态与肿瘤部位和组织学类型均无关,并发2型糖尿病和结肠肠梗阻比例较低,分别为3.89%和3.69%。结论术前CEA阴性结直肠癌发病年龄提前,发病人群较年轻,老年化趋势比较慢,与血型A和B有一定的关联,临床上并发2型糖尿病和肠梗阻比例较低。防治上采取关口前移的策略可能更富有成效和针对性。
Objective To understand the clinical and epidemiological characteristics of serum CEA negative colorectal cancer. Methods A retrospective analysis of 1969 newly diagnosed colorectal cancer hospitalized cases with serum CEA test results from January 2003 to December 2010 was performed. The data of colorectal cancer between the two groups were compared in serum CEA negative and CEA positive. Results The mean age at onset of preoperative CEA negative colorectal cancer was (55.89 ± 13.68) years old compared with CEA positive colorectal cancer, which was younger than 2 years old. The median age of onset was 56 years old, Years old; the incidence of young people under the age of 60 accounted for the majority, of which a higher proportion of blood type A, while the proportion of blood type B was lower; serum CEA expression status and tumor location and histological type have no correlation, complicated by 2 The proportion of type 2 diabetes mellitus and colon ileus was lower, 3.89% and 3.69% respectively. Conclusions Preoperative CEA-negative colorectal cancer has an earlier age of onset, a younger age of onset, a slower aging trend, and a certain association with blood type A and B, with a lower incidence of type 2 diabetes mellitus and intestinal obstruction. Prevention and treatment to take the gateway to move forward strategy may be more fruitful and targeted.