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在微波辐射无溶剂条件下,以鹅去氧胆酸甲酯为隔离剂,通过氨基与不同芳香醛缩合合成了十个含席夫碱结构单元为手臂的新型鹅去氧胆酸分子钳.通过微波法和常规法的对比发现,使用微波法后,产率从30%~75%提高到85%~94%,反应时间从300~480 min缩短到0.5~1.5 min.所有合成化合物的结构均经1H NMR,IR,ESI-MS和元素分析确证.利用紫外光谱滴定法考察了其对分子的识别性能研究.实验结果表明,这类分子钳人工受体对有机小分子具有良好的识别能力.
Ten novel chenodeoxycholic acid molecular tweezers containing Schiff base structural units as the arms were synthesized by condensing amino groups with different aromatic aldehydes under the conditions of solvent-free microwave irradiation and methyl chenodeoxycholate as a release agent. The comparison between the microwave method and the conventional method showed that the yield of microwave irradiation was increased from 30% -75% to 85% -94% and the reaction time was shortened from 300-480 min to 0.5-1.5 min by microwave method.The structures of all the synthesized compounds The results of 1H NMR, IR, ESI-MS and elemental analysis confirmed that the recognition performance of the molecule was investigated by ultraviolet spectrophotometry.The experimental results show that these molecular clamp artificial receptors have good recognition ability for small organic molecules.