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Carvedilol是一种新型的、非选择性阻滞β受体和选择性阻滞α_1受体的药物。它可有效地治疗轻度、中度高血压,并且对心绞痛也有效。最近,几种实验模型证明,carvedilol能减轻冠状动脉闭塞所致的心肌损伤,这种心脏保护作用曾被认为与降低心脏负荷和氧需求量有关。然而,据最近报道,某些β受体阻断剂能抑制犬肌纤维膜上铁依赖性自由基系统引起的过氧化脂质(LPO),并且保护犬心肌细胞免受氧自由基的损伤。这些结果提示,抑制LPO也可能与β受体阻滞剂对心脏的保护作用有关。因此,在本项研究中,观察了carvedilol对猪心室细胞膜上铁依赖性
Carvedilol is a novel, non-selective block β receptor and selective block α 1 receptor drugs. It is effective in treating mild to moderate hypertension and is also effective in angina. Recently, several experimental models demonstrated that carvedilol attenuated myocardial damage caused by occlusion of the coronary arteries. This cardioprotective effect was previously thought to be associated with decreased cardiac load and oxygen demand. However, it has recently been reported that certain beta-blockers inhibit peroxisomal lipid (LPO) induced by the iron-dependent free radical system in canine muscle fibers and protect canine cardiomyocytes against oxygen free radicals. These results suggest that inhibition of LPO may also be related to the protective effects of beta-blockers on the heart. Therefore, in the present study, iron dependence of carvedilol on porcine ventricular cell membranes was observed