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阿尔葡西酶(alglucerase,简称Alg)是一种末端为甘露糖的来自人体胎盘的葡萄糖脑苷脂酶。本品对高歇氏病(GD)有治疗作用。在Alg iv治疗后6个月内可见明显效果,病人血红蛋白和血小板数增加,鼻衄、青肿发生率减少,肝、脾体积减小,骨骼参数改善。儿童身高增加。大多数经Alg治疗的病人恢复工作和日常活动。Alg耐受性好,极少有轻度不良反应的报道。对GD病人在治疗方法有限的情况下,用Alg作酶替代疗法可作为第一线的治疗手段。
Alglucerase (Alglucerase, abbreviated Alg) is a glucocerebrosidase derived from human placenta with mannose end. This product has a therapeutic effect on Gaucher’s disease (GD). Within 6 months after Alg iv treatment, the obvious effect was found. The hemoglobin and platelet count increased, the incidence of epistaxis and bruise decreased, the volume of liver and spleen decreased, and the skeletal parameters improved. Children’s height increased. Most Alg-treated patients resume their work and daily activities. Alg is well tolerated with few reports of mild adverse events. For patients with GD in the treatment of limited circumstances, with Alg for enzyme replacement therapy can be used as a first-line treatment.