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采用脑薄片方法，观察损毁中缝背核（DR）、不同光照条件、5-羟色胺（5－HT）、氯氮平和利坦色林对视交叉上核（SCN）神经元昼夜自发放电的影响。结果：①SCN有昼高夜低的自发放电的节律性；②5－HT对SCN神经元自发放电有抑制作用，SCN神经元对5－HT的敏感性呈昼低夜高的节律（P＜0.01）；③氯氮平和利坦色林均能阻断5－HT对SCN神经元自发放电的抑制作用；④损毁DR后，SCN神经元对5－HT的敏感性增高，结果提示5－HT7样受体可能参与DR的5－HT能纤维对SCN神经元的调节作用。
The effects of dorsal raphe nucleus (DR), different light conditions, 5-hydroxytryptamine (5-HT), clozapine and litan-tanning on the spontaneous and diurnal spontaneous discharges of the suprachiasmatic nucleus (SCN) neurons were observed by using brain slices method. RESULTS: SCN had rhythmicity of spontaneous discharge with high daytime and nighttime; ②The inhibitory effect of 5-HT on spontaneous discharge of SCN neurons; the sensitivity of SCN neurons to 5-HT was rhythm of daytime low night and high night (P <0.01) ; ③ Clozapine andLatanserin can block 5-HT on SCN neuronal spontaneous discharge inhibition; ④ damage DR, SCN neurons on 5-HT sensitivity increased, the results suggest that 5-HT7-like receptor Body may participate in the regulation of SCN neurons by 5-HT fibers of DR.