丘脑下部——垂体功能调节中的甲状腺素脱碘作用

• 作 者: 刘皓
• 出 处: 国外医学.内分泌学分册
• 发表日期: 1985年01期
• 关键词: 垂体功能 甲状腺素 丘脑下部 脱碘作用 脱碘 甲状腺激素 甲状腺 脱碘酶 活体内 大鼠

近年来,甲状腺激素对丘脑下部和垂体功能的细胞内影响正为人们进一步了解。有关甲状腺激素在靶器宫中脱碘调节的研究也正在深入。甲状腺素(T_4)是甲状腺产生的,但是T_4的脱碘代谢是在甲状腺外进行的。在人和大鼠活体内,T_4脱碘发生在酚环上和酪氨环上的比率大致相等,这些反应在人体产生70%～80%的T_3和全部的rT_3。然而,甲状腺素脱碘的研究是重要的。

In recent years, thyroid hormone on the hypothalamus and pituitary function of the intracellular effects are being further understood. Research on the regulation of thyroid hormones in deiodination in the target organ is also under way. Thyroid hormone (T_4) is produced by the thyroid gland, but deiodination of T_4 occurs outside the thyroid. In humans and rats, T_4 deiodination occurs approximately equally on the phenolic ring and the tyramide ring. These reactions produce 70% to 80% of T_3 and all of rT_3 in humans. However, the study of thyroxine deiodination is important.