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目的：探讨脑出血大鼠局部脑血流量（ｒＣＢＦ）变化规律及脑出血后继发性脑缺血与脑水肿的关系。方法：采用新鲜未肝素化自体动脉血注入大鼠尾状核建立脑出血模型，以氢清除法测定ｒＣＢＦ，以干湿重法测定脑水分含量，观察脑出血后２４小时内两侧尾状核、丘脑和额叶皮质ｒＣＢＦ和脑各部位水分含量的变化。结果：脑出血后血肿周围脑组织ｒＣＢＦ迅速下降，出血４小时起脑水分含量明显增加，血肿远隔区同样受到影响。脑水肿区域与ｒＣＢＦ下降范围基本一致，但脑出血后２４小时内脑水肿高峰期迟发于ｒＣＢＦ下降高峰期。结论：实验大鼠脑出血后存在广泛脑缺血和严重脑水肿；ｒＣＢＦ下降是脑水肿发生、发展的重要原因
Objective: To investigate the changes of regional cerebral blood flow (rCBF) and the relationship between cerebral ischemia and cerebral edema after intracerebral hemorrhage in rats. Methods: Intracerebral hemorrhage model was established by injecting fresh non-heparinized autologous arterial blood into the caudate nucleus of rat to determine rCBF by hydrogen scavenging method. The content of brain water was measured by dry-wet method. The caudate nucleus of both sides within 24 hours after intracerebral hemorrhage , Thalamic and frontal cortex rCBF and various parts of the brain water content changes. Results: After intracerebral hemorrhage, the rCBF decreased rapidly in brain tissue and the brain water content increased obviously 4 hours after hemorrhage. The hematoma distant area was also affected. Cerebral edema area and rCBF decline in the range of the same, but within 24 hours after intracerebral hemorrhage, cerebral edema peak lag rCBF peak. Conclusion: There is extensive cerebral ischemia and severe cerebral edema after intracerebral hemorrhage in experimental rats. The decrease of rCBF is an important reason for the occurrence and development of cerebral edema