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消炎痛(Indomethacin)是一种非甾体抗炎剂(NSAIA),具有解热,镇痛,消炎作用。口服约3小时或栓剂约1小时,血药浓度达高峰,半衰期约3小时。消炎痛口服吸收迅速而完全,吸收后约有90％与血浆蛋白结合,经肝脏转化,2/3以葡萄糖醛酸苷形式从肾脏随尿液排出,其余部分随粪便排出。 1971年Vane首先阐明消炎痛,阿斯匹林等NSAIA的作用机制主要是抑制前列腺素(PG)的生物合成。随着PG研究的进
Indomethacin is a non-steroidal anti-inflammatory agent (NSAIA) with antipyretic, analgesic and anti-inflammatory effects. Oral for about 3 hours or suppository about 1 hour, the plasma concentration reached its peak, half-life of about 3 hours. Indomethacin orally absorbed quickly and completely, after absorption, about 90% of plasma protein binding, the liver transformed, 2/3 in the form of glucuronide with the urine from the kidneys, and the rest with the excretion. 1971 Vane first clarified that indomethacin, aspirin and other NSAIA mechanism of action is mainly inhibited prostaglandin (PG) biosynthesis. With the progress of PG research