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目的:探讨影响早产儿医院感染的有关因素。方法:回顾性分析2003~2007年250例早产儿医院感染的发生情况,并分析孕周、出生体重、机械通气、抗生素、丙种球蛋白、使用胃肠外营养与发生医院感染的关系。结果:早产儿医院感染率为9.2%,出生体重与感染有相关性,机械通气与感染有明显相关性,孕周、抗生素、丙种球蛋白、胃肠外营养与感染无相关性。结论:早产儿中的小于胎龄儿更易发生医院感染,机械通气是早产儿感染的重要影响因素,胃肠外营养不增加医院感染率,使用抗生素和丙种球蛋白无助于减少早产儿医院感染的发生。
Objective: To explore the influencing factors of nosocomial infection in premature infants. Methods: The incidence of nosocomial infection in 250 preterm infants from 2003 to 2007 was retrospectively analyzed. The relationship between nosocomial infection and gestational age, birth weight, mechanical ventilation, antibiotics, gamma globulin and parenteral nutrition were analyzed. Results: The rate of nosocomial infection in premature infants was 9.2%, birth weight was related to infection, and mechanical ventilation was significantly related to infection. There was no correlation between gestational age, antibiotics, gamma globulin, parenteral nutrition and infection. CONCLUSIONS: Premature infants with less than gestational age are more likely to have nosocomial infections. Mechanical ventilation is an important contributor to preterm infant infection. Parenteral nutrition does not increase nosocomial infection rates. Use of antibiotics and gamma globulin does not contribute to the reduction of nosocomial infections in preterm infants happened.