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目的 了解2016年安徽省滁州地区细菌耐药性监测结果.方法 采用纸片扩散法(K-B法)对滁州地区6所医院所分离菌株进行药敏试验,按CLSI 2015版标准判断结果,采用WHONET5.6进行耐药性分析.结果 2016年共收集临床分离菌5 465株,其中革兰阳性菌1 416株,占25.9％; 革兰阴性菌4 049株,占74.1％.葡萄球菌属中耐甲氧西林金黄色葡萄球菌(MRSA)和耐甲氧西林凝固酶阴性葡萄球菌(MRCNS)分别占各自菌种的37.6％和78.1％.葡萄球菌属及肠球菌属中未见万古霉素和利奈唑胺耐药株.大肠埃希菌、克雷伯菌属(肺炎克雷伯菌和产酸克雷伯菌)和奇异变形杆菌超广谱β内酰胺酶(ESBL)的检出率分别为51.2％、23.4％和23.6％.肠杆菌科细菌对美罗培南和亚胺培南较敏感.铜绿假单胞菌对所检测的抗菌药物耐药率均低于30％.不动杆菌属对美罗培南和亚胺培南的耐药率分别为65.6％和67.4％.结论 细菌的耐药性日趋严重,多重耐药和泛耐药菌株应引起高度重视.“,”Objective To investigate the bacterial resistance profile of clinical isolates collected in the hospitals across Chuzhou in 2016. Methods Antimicrobial susceptibility testing was carried out by Kirby-Bauer method. The data were analyzed using WHONET 5.6 software according to CLSI 2015 breakpoints. Results A total of 5 465 clinical isolates were collected during 2016, of which gram positive organisms and gram negative organisms accounted for 25.9％ (1 416/5 465) and 74.1％ (4 049/5 465), respectively. Prevalence of MRSA was 37.6％ among S. aureus and the prevalence of MRCNS was 78.1％ in CNS. All Staphylococcus, E. faecalis and E. faecium isolates were sensitive to vancomycin and linezolid. The prevalence of extended spectrum-lactamases (ESBLs) positive strains was 51.2％ in E. coli, 23.4％ in Klebsiella spp. (K. pneumoniae and K. oxytoca), and 23.6％ in P. mirabilis isolates, respectively. The Enterobacteriaceae strains were highly sensitive to carbapenems. The percentage of the P. aeruginosa isolates resistant to the antimicrobials tested was lower than 30％. The percentage of the Acinetobacter strains resistant to meropenem and imipenem was 65.6％ and 67.4％, respectively. Conclusions The situation of antibiotic resistance is still very serious, especially multi-drug or pan-drug resistant strains, which is of great concern.