论文部分内容阅读
目的 探讨新生儿缺氧缺血性脑病 (HIE)时血浆内皮素 (ET)、头颅CT以及新生儿行为神经测定(NBNA)三项检测在不同时期的变化及其相互关系 ,评估此三项指标单一及相结合后对临床的指导意义。方法 放射免疫法检测HIE患者不同时期的血浆ET值 ,同时进行头颅CT及NBNA检测。结果 ET值的升高与临床中重度病情关系密切。而升高的持续时间可能与预后关系较大 ;头颅CT在早期与临床的符合率不足 70 % ,因而早期CT正常不能排除HIE ;NBNA测定结果则与HIE的临床经过基本一致 ,但其缺点是易受到新生儿状态的影响。结论 三种指标相结合可以更为有利于客观地判断病情 ,指导治疗和预后 ,进而有利于开展早期干预 ,减少致残
Objective To investigate the changes and their correlations of plasma endothelin (ET), cephalometric CT and neonatal behavioral nerve assay (NBNA) in different stages of neonatal hypoxic-ischemic encephalopathy (HIE) Single and combination of clinical significance. Methods Radioimmunoassay was used to detect plasma ET in different periods of HIE patients. CT and NBNA were also performed. Results The rise of ET was closely related to the moderate and severe clinical conditions. While the duration of the increase may have a great relationship with the prognosis. The coincidence rate of cranial CT in early stage and clinical stage is less than 70%, so early CT can not rule out HIE. The NBNA results are basically consistent with the clinical course of HIE, but the disadvantage is Easily affected by the status of the newborn. Conclusion The combination of the three indicators can be more conducive to objectively determine the condition, guide the treatment and prognosis, and then conducive to early intervention to reduce disability