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本实验采用不同途径给予断乳Wistar大鼠小剂量(0.05mg/kg、0.025mg/kg)氯化角钐(SmCl3)、氯化镨(PrCl3)后,测定了肝脏中过氧化脂质(LPO)和超氧化物歧化酶(SOD)的含量,观察了肝脏的超微结构。结果表明:SmCl3和PrCl3均使肝脏中LPO活性降低、SOD活性升高,二者比较PrCl3的作用更为明显,肝脏未见明显形态学改变。
In this study, different doses of Wistar rats were given low dose (0.05mg / kg, 0.025mg / kg) of samarium chloride (SmCl3) and praseodymium chloride (PrCl3) (LPO) and superoxide dismutase (SOD) levels were observed in the liver ultrastructure. The results showed that both SmCl3 and PrCl3 reduced LPO activity and SOD activity in the liver, and the effect of PrCl3 was more obvious than that of PrCl3. No obvious morphological changes were observed in the liver.