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目的比较丙泊酚单独用药与复合用药在人工流产术中的镇痛效果。方法将妇产科门诊符合要求并自愿行无痛人工流产术的受孕妇女240例,按随机数字表分为A、B、C3组,每组80例。A组丙泊酚单独用药,B组丙泊酚复合枸橼酸芬太尼,C组丙泊酚复合枸橼酸芬太尼、盐酸利多卡因。观察3组在无痛人工流产术术前、术中、术后BP、HR、SpO2的变化,以及术中、术后的镇痛效果,计算各组丙泊酚的用量,各组在推注丙泊酚时引起疼痛的程度。结果 3组均取得了比较满意的麻醉效果,A组术后下腹疼痛者11例,B、C组无术后下腹疼痛者,C组术后镇痛效果优于A、B组,BP、HR、SpO2变化差异有统计学意义(P均<0.05)。结论丙泊酚虽是一种理想的静脉麻醉药,但单独使用时用量较大,镇痛效果偏差,对呼吸、循环影响较大。而复合用药明显优于单独用药,其中丙泊酚复合枸掾酸芬太尼、盐酸利多卡因,麻醉效果好,丙泊酚用量少,副作用小,更适用于门诊无痛人工流产术。
Objective To compare the analgesic effect of propofol alone and compound in abortion. Methods A total of 240 pregnant women who met the requirements of obstetrics and gynecology clinics and performed voluntary painless abortion were divided into A, B and C3 groups according to random number table, 80 cases in each group. Group A received propofol alone, Group B propofol combined with fentanyl citrate, Group C propofol combined with fentanyl citrate and lidocaine hydrochloride. The changes of BP, HR and SpO2 before, during and after painless artificial abortion were observed and the analgesic effects during and after operation were observed in 3 groups. The dosage of propofol in each group was calculated, The degree of pain caused by propofol. Results All the three groups were satisfied with anesthesia. Among the patients in group A, there were 11 cases of abdominal pain after operation. There was no postoperative abdominal pain in group B and C. The postoperative analgesic effect of group C was better than that of group A and B, BP, HR , SpO2 changes were statistically significant (P all <0.05). Conclusion Although propofol is an ideal intravenous anesthetic, when used alone, the dosage is large, the analgesic effect is poor, and the effect on respiration and circulation is greater. The combination of drugs was significantly better than the single drug, which propofol compound fentanyl citrate, lidocaine hydrochloride, anesthesia, propofol with less dosage, side effects, more suitable for out-patient painless abortion.