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腹泻是影响到发展中国家旅游的旅游者最常见的疾病.作者进行了前瞻性随机双盲、安慰对照试验,旨在研究早期使用单剂量环丙沙星经验治疗旅游者腹泻的疗效.参试者为1993年5～11月在到达伯利兹的最初8周内发生腹泻的英国军队,剔除大便带血、高热(>38.5℃)或需静脉输液治疗的严重脱水者.所有患者每周口服氯喹和每日口服氯胍作为疟疾预防用药.在治疗开始后72h或彻底痊愈以前,记录每一患者的大便性状、次数及腹疼、呕吐等相关临床症状.以末次液体样大便时间和末次不成形大便时间来确定患者腹泻时间,以治疗后24、48和72h液体样大便和不成形大便的累积患者人数评估疾病的严重程度.
Diarrhea is the most common disease that affects travelers traveling to developing countries and the authors conducted a prospective, randomized, double-blind, placebo-controlled trial to study the early experience of using a single dose of ciprofloxacin for the treatment of diarrhea in tourists. Who died of diarrhea within the first 8 weeks of arriving in Belize from May to November 1993, excluding severe bloody stools with bloody stools, high fever (> 38.5 ° C) or intravenous fluids, and all patients were orally given chloroquine And daily oral administration of proguanil as malaria prophylaxis.Patient traits and frequency of each patient and related clinical symptoms such as abdominal pain and vomiting were recorded before 72 h or after complete cure.According to the last liquid-like stool time and the last non-forming Stool time to determine the patient’s diarrhea time, the cumulative number of patients with liquid-like stools and non-shaped stool 24, 48 and 72h after treatment to assess the severity of the disease.