论文部分内容阅读
目的分析200例头孢菌素抗生素的ADR(不良反应)报告,促进临床抗生素使用的合理、科学化。方法选取我院于2012年4月-2016年7月间收治的200例使用头孢菌素类抗生素治疗所致不良反应患者进行研究,对患者临床资料给予回顾性分析,统计不良反应发生情况。结果①就头孢菌素类药物不良反应而言,有61例患者因使用头孢曲松发生不良反应,比例为30.5%,所占百分比最高,其次为头孢他啶(19.5%)以及头孢呋辛(13.5%)。②从给药途径上看,以静脉注射用药患者居多,比例为97.0%(194/200),明显高于口服(2.0%)、皮内注射(1.0%)患者的不良反应率。③在不良反应表现方面多数病患为皮疹、红斑,比例为60.5%(121/200)。结论临床必须加强对头孢菌素类药物使用的管理,密切监测患者不良反应发生情况,采取合理措施预防药物副作用。
Objective To analyze 200 cases of cephalosporin antibiotic ADR (adverse reaction) report, to promote the rational use of antibiotics, scientific. Methods A total of 200 adverse reactions caused by cephalosporin antibiotics were studied in our hospital from April 2012 to July 2016. The clinical data of patients were retrospectively analyzed and the incidence of adverse reactions was calculated. Results ① For the adverse reactions of cephalosporins, 61 patients had adverse reactions due to ceftriaxone, accounting for 30.5%, the highest percentage, followed by ceftazidime (19.5%) and cefuroxime (13.5% ). ② From the perspective of route of administration, the majority of patients taking intravenous drug were 97.0% (194/200), which was significantly higher than those of oral (2.0%) and intradermal injection (1.0%) patients. ③ The majority of patients showed rash and erythema in adverse reactions, with a ratio of 60.5% (121/200). Conclusion The clinical management of cephalosporins should be strengthened, the adverse reactions of patients should be closely monitored, and reasonable measures should be taken to prevent side effects of drugs.