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在非水条件下 ,醇 (R1 R2 R3COH)和腈 (R4 CN)加硫酸氢镁在室温至 90°C反应 ,可方便地转化为 N -取代的酰胺(R4 CONHCR1 R2 R3)。试剂稳定易得且无毒性 ,操作简便 ,31例收率 6 9%～ 97%。醇和腈转化为N-取代酰胺@刘玲玲
Under non-aqueous conditions, the alcohol (R1 R2 R3COH) and the nitrile (R4CN) plus magnesium bisulfate react conveniently at room temperature to 90 ° C and are conveniently converted to the N-substituted amide (R4 CONHCR1 R2 R3). Reagents are stable and readily available and non-toxic, easy to operate, 31 cases yield 69% ~ 97%. Conversion of alcohols and nitriles to N-substituted amides @ Lingling Liu