论文部分内容阅读
感染抗氯喹系伯氏原虫小鼠,ig咯萘啶6mg/kg后15min～24h,用电镜观察红内期形态变化,发现滋养体复合膜最早受损,呈肿胀,形成多层螺纹膜,且进行性加重;随后,线粒体肿胀、内质网消失、核糖体模糊、核质致密。最后普遍查见小的、破裂的死虫。而经氯喹400mg/kg作用后的RC原虫,绝大多数红内期的超微结构无变化。表明咯萘啶对RC红内期原虫有直接杀灭作用,提示滋养体复合膜的最早受损可能是RC原虫对咯萘啶无交叉抗性的原因。
Infected with chloroquine-resistant Beauveria bassiana mice, ig pyronaridine 6mg / kg after 15min ~ 24h, observed by electron microscopy within the red-phase morphological changes found that trophozoite composite membrane was the earliest damage, swelling, the formation of multi-threaded membrane, and Progressive increase; Subsequently, the mitochondria swelling, disappearance of endoplasmic reticulum, ribosome fuzzy, dense nuclear. In the end it is common to find small, ruptured dead insects. The RC protozoa after chloroquine 400mg / kg role, the vast majority of red-phase ultrastructure did not change. The results showed that pyronaridine had a direct killing effect on RC red protracted protozoa, suggesting that the earliest damage of trophozoite composite membrane may be the reason that RC protozoa had no cross resistance to pyronaridine.