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为探讨人细小病毒Ｂ１９（ＨＰＶＢ１９） 所致再生障碍性贫血（ＡＡ） 的免疫学改变， 应用酶联免疫吸附试验检测ＡＡ 患儿血清白细胞介素８ 和６ （ＩＬ８、ＩＬ６）、肿瘤坏死因子α（ＴＮＦα） 及干扰素α（ＩＦＮα） 水平。结果： ＡＡ 患儿上述各免疫指标水平均显著高于正常对照组（Ｐ＜ ０－０１ 或Ｐ＜ ０－０５） 。其中ＨＰＶＢ１９ 阳性ＡＡ 组ＩＬ８ 水平亦高于ＨＰＶＢ１９ 阴性组， 而ＩＬ６、ＴＮＦα及ＩＦＮα两组间无差异。对ＨＰＶＢ１９ ＡＡ组作直线相关分析显示， ＩＬ８ 与ＴＮＦα和ＩＦＮα呈正相关， ＴＮＦα与ＩＬ６ 呈正相关（ｒ 分别为０－５６５ 、０－６０３ 及０－８６０， Ｐ＜ ０－０１） 。提示： ＨＰＶＢ１９ 所致ＡＡ 患儿有明显的免疫功能紊乱， 多种细胞因子， 特别是ＩＬ８ 可能在其免疫病理机制中起一定作用。
To investigate the immunological changes of aplastic anemia (AA) caused by human parvovirus B19 (HPVB19), serum interleukin-8 and IL-8 (IL-8 and IL-6) were detected by enzyme-linked immunosorbent assay Tumor necrosis factor alpha (TNF @) and interferon alpha (IFN @) levels. Results: The levels of above mentioned immune indexes in AA children were significantly higher than those in normal controls (P <0-01 or P <0-05). Which HPVB19-positive AA group IL 8 level is also higher than HPVB19-negative group, while IL 6, TNF α and IFN α no difference between the two groups. For the HPVB19 AA group for linear correlation analysis showed that IL 8 and TNF α and IFN α was positively correlated, TNF α and IL 6 was positively correlated (r were 0-565, 0-603 and 0-860, P <0-01). Tip: AA children with HPVB19 obvious immune dysfunction, a variety of cytokines, especially IL 8 may play a role in its immune pathology.