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因故突停心得安产生一系列之临床表现,称之为心得安停药综合征。一、临床表现:(一)使缺血性心脏病加重:本征最早被发现是心绞痛因突停心得安而发生心肌梗塞。梶原氏等在20例心绞痛病人行双盲对照试验,突停心得安或安慰剂,在用心得安160~320mg/d共6~12周中,无1例使用硝酸甘油,也无疾病恶化者。但在突停心得安后2周内,10例出现了心脏缺血现象,6例发生严重心脏并发症;但突停安慰剂者,则只4例心绞痛加重,无任何缺血现象。(二)使心律不齐发生率增加:Swant氏在1000例心肌梗塞中有154例给予心得安,持续服药者虽有8例见到了室性早搏,但无出现室上性心动过速者,其中97例突然
For some reason, sudden onset of anxiety produces a series of clinical manifestations, known as cardiac arrest syndrome. First, the clinical manifestations: (A) to increase the risk of ischemic heart disease: the earliest was found to be angina due to sudden cardiac arrest and myocardial infarction. Ebara so in 20 cases of angina patients underwent double-blind controlled trials, sudden cardiac propofol or placebo in the heart with anorexia 160 ~ 320mg / d for a total of 6 to 12 weeks, no 1 case of nitroglycerin, no disease worsening . However, within 2 weeks after the sudden cardiac arrest, 10 patients developed cardiac ischemia and 6 had severe cardiac complications. However, only 4 patients with sudden cardiac arrest had aggravated angina without any ischemia. (B) to increase the incidence of arrhythmia: Swant’s in 1000 cases of myocardial infarction in 154 cases of propranolol, continuous medication although 8 cases of premature ventricular contractions seen, but no supraventricular tachycardia, 97 of them suddenly