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在未合并人类免疫缺陷病毒(HIV)感染的早期梅毒患者中,神经梅毒极为罕见。对青霉素过敏的早期梅毒患者的常规治疗是用强力霉素100mg,每日2次共2周。虽然强力霉素可以通过血脑屏障达到杀灭密螺旋体的浓度,但对其预防随后发生神经梅毒的效果还未作过研究。作者报告1例经强力霉素治疗的早期潜伏梅毒患者1年后被诊断为无症状神经梅毒。患者女,50岁,因近来与早期潜伏梅毒患者有无保护性性接触史,而于1991年7月就诊。患者既往无梅毒史,无任何临床症状。但于1991年5月在治疗外阴阴道念珠菌病时曾作过RPR试验,结果为1:1,FTA-ABS试验,结果为4+,当时未
Neurosyphilis is extremely rare in early syphilis patients who do not have a human immunodeficiency virus (HIV) infection. The usual treatment for early syphilis allergy to penicillin is with doxycycline 100 mg twice daily for 2 weeks. Although doxycycline can reach the concentration of Treponema pallidum through the blood-brain barrier, its effect on preventing subsequent neurosyphilis has not been studied. The authors report that one case of early latent syphilis treated with doxycycline was diagnosed as asymptomatic neurosyphilis one year later. The woman, 50 years old, was treated in July 1991 for her recent history of protective contact with patients with latent latent syphilis. No past history of patients with syphilis, without any clinical symptoms. However, in May 1991 in the treatment of vulvovaginal candidiasis had made RPR test, the result was 1: 1, FTA-ABS test, the result was 4 +, when not