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对测定血清α_１－抗胰蛋白酶（α_１－ＡＴ）常用的酶法和免疫测定法进行了比较。结果表明，火箭免疫电泳法的灵敏度、准确性优于酶法。用这两种方法同时测定癌性及非癌性肺疾病患者的血清α_１－ＡＴ，与正常对照组比较，肺癌及非癌性肺疾病组血清α_１－ＡＴ水平均明显增高；用免疫测定法测定的结果还显示，肺癌组血清α_１－ＡＴ高于非癌性肺疾病组，差异有显著性。提示血清α_１－ＡＴ的改变可能对肺癌的临床诊断和鉴别有参考价值。
The enzymatic and immunoassay methods commonly used for the determination of serum α 1 -antitrypsin (α 1 -AT) were compared. The results show that the sensitivity and accuracy of rocket immunoelectrophoresis is better than enzymatic method. Using these two methods to simultaneously measure serum α 1 -AT in patients with cancerous and non-cancerous lung diseases, compared with the normal control group, serum α 1 -AT levels in lung cancer and non-cancerous lung disease groups were significantly higher; measured by immunoassay The results also showed that the serum α 1 -AT in the lung cancer group was higher than that in the non-cancerous lung disease group, and the difference was significant. It suggests that the change of serum α_1-AT may have reference value for clinical diagnosis and differential diagnosis of lung cancer.