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用免疫组化方法观察４５例大肠腺瘤和６１例大肠腺癌中ｂｃ１－２和ｐ５３蛋白的表达。结果显示：正常大肠粘膜中ｂｃ１－２和ｐ５３均未见表达，而大肠腺瘤及大肠腺癌阳性率均较正常组织明显增加（Ｐ＜０．０１）．大肠腺瘤中ｂｃ１－２表达位于不典型增生较重区域。大肠腺瘤ｐ５３表达随腺瘤直径增加而增加，其中≥２０ｍｍ组阳性率显著高于＜１０ｍｍ组（ｐ＜０．０５）。ｐ５３蛋白阳性率也随不典型增生程度增加而增高。ｐ５３表达与大肠腺癌分化程度及Ｄｕｋｅｓ分期有关。大肠腺瘤中ｂｃ１－２和ｐ５３蛋白的表达呈负相关。结果表明，ｂｃ１－２蛋白表达对大肠腺瘤的增殖有一定意义，ｐ５３在大肠腺瘤癌变和大肠腺癌进展中起重要作用。
Immunohistochemistry was used to observe the expression of bcl-2 and p53 protein in 45 cases of colorectal adenoma and 61 cases of colorectal adenocarcinoma. The results showed that there was no expression of bcl-2 and p53 in normal colorectal mucosa, but the positive rate of colorectal adenoma and colorectal adenocarcinoma was significantly higher than that in normal tissue (P<0.01). Bcl-2 expression in colorectal adenomas is located in the heavier areas of dysplasia. The expression of p53 in colorectal adenomas increased with the diameter of adenomas. The positive rate of ≥20 mm group was significantly higher than that of <10 mm group (p<0.05). The positive rate of p53 protein also increased with the increase of atypical hyperplasia. The expression of p53 is related to the differentiation of colorectal adenocarcinoma and the Dukes stage. The expression of bcl-2 and p53 protein was negatively correlated in colorectal adenomas. The results showed that the expression of bcl-2 protein has a certain significance on the proliferation of colorectal adenoma. p53 plays an important role in the progression of colorectal adenoma and the progression of colorectal adenocarcinoma.