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目的:探讨冠心病患者腹部内脏脂肪与冠状动脉狭窄程度的关系。方法:选自2007-11-2009-03在我院经冠状动脉造影证实为冠心病的206患者为研究对象。记录身高、体重、腰围、血压等,检测受试者的血脂、空腹血糖、尿酸、肾功能等指标,采用定量Gensini积分评价患者冠状动脉狭窄的程度,同时应用超声测量腹部内脏脂肪厚度(visceral fat thick ness,VFT),根据VFT值将患者分为低、中、高值3组。结果:与低值组比较,中、高值组患者腰围、体质指数较大,TG明显增高,HDL-C水平显著降低。随着腹部内脏脂肪厚度的增加,Gensini积分明显增大。Gensini积分与年龄、腰围、体质指数、TG、LDL-C、VFT呈正相关,与HDL-C呈负相关。多元回归分析显示年龄,LDL-C、糖尿病和VFT是冠状动脉狭窄的独立危险因素,但是校正腰围后VFT不再有统计学意义。结论:冠心病患者VFT与冠状动脉狭窄呈明显正相关,VFT测量可以作为冠心病患者危险评估的有用指标。
Objective: To investigate the relationship between abdominal visceral fat and coronary stenosis in patients with coronary heart disease. Methods: From 2007-11-2009-03 in our hospital confirmed by coronary angiography of coronary heart disease in 206 patients for the study. The subjects’ blood lipids, fasting blood glucose, uric acid and renal function were recorded, and the degree of coronary artery stenosis was evaluated by quantitative Gensini score. At the same time, the visceral fat thickness thick ness, VFT), according to the VFT value will be divided into low, medium and high value 3 groups. Results: Compared with the low value group, the waist and body mass index of the middle and high value group were larger, TG was significantly higher, HDL-C was significantly lower. As abdominal visceral fat thickness increased, Gensini score significantly increased. Gensini score was positively correlated with age, waist circumference, body mass index, TG, LDL-C, VFT and negatively correlated with HDL-C. Multivariate regression analysis showed that age, LDL-C, diabetes mellitus and VFT were independent risk factors for coronary artery stenosis, but VFT no longer statistically significant after waist circumference correction. Conclusion: There is a positive correlation between VFT and coronary artery stenosis in patients with coronary heart disease. VFT measurement can be used as a useful indicator of risk assessment in patients with coronary heart disease.