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目的 :探讨急性白血病患儿与血清IL-10、IFN-γ水平的相关性,分析急性白血病可能的免疫逃逸机制。方法 :回顾性分析我院2011年5月至2014年8月期间收治的84例急性白血病患儿的临床资料,所有患儿均采用ELISA法测定其血浆IL-10、IFN-γ水平。结果 :急性白血病患儿血浆中IL-10浓度明显高于对照组,IFN-γ水平明显低于对照组;经化疗后,完全缓解组、部分缓解组、死亡组患儿治疗前血浆中IL-10浓度依次升高,IFN-γ浓度则依次降低。结论 :急性白血病初发患儿体内Th2型细胞占绝对优势,导致肿瘤局部呈现免疫抑制状态,可能是急性白血病的一个免疫逃逸机制。肿瘤局部Th1型细胞因子极度缺乏,而Th2型细胞因子明显增多,说明患儿可能存在预后不良。故临床实践中可通过测定Th1、Th2型细胞因子评估患儿的免疫状态及预后情况。
Objective: To investigate the correlation between serum IL-10 and IFN-γ in children with acute leukemia and to analyze the possible mechanism of immune escape in acute leukemia. Methods: The clinical data of 84 children with acute leukemia admitted from May 2011 to August 2014 in our hospital were retrospectively analyzed. The levels of plasma IL-10 and IFN-γ in all children were measured by ELISA. Results: The plasma concentration of IL-10 in children with acute leukemia was significantly higher than that in the control group, and the level of IFN-γ was significantly lower than that in the control group. After chemotherapy, the levels of IL- 10 concentration in turn increased, IFN-γ concentration decreased in turn. Conclusion: Th2-type cells account for the absolute predominance of acute leukemia in children with initial onset of immunosuppression and may be an immune escape mechanism of acute leukemia. Local tumor Th1-type cytokines lack of extreme, and Th2-type cytokines increased significantly, indicating that children may have poor prognosis. Therefore, clinical practice can be measured by Th1, Th2 type cytokines in children with immune status and prognosis.